Conditional Epistatic Interaction Maps Reveal Global
Functional Rewiring of Genome Integrity Pathways
in Escherichia coli
Kumar. et al. (2015)
Supporting Materials
Tables
- Table S1 - List of 549 genes targeted for eSGA screening.
- Table S2 - List of gene pairs with GI scores in static (UT and MMS) networks.
- Table S3 - Comparison of GIs from static networks to literature curated gene pairs.
- Table S4 - Correlation coefficient score for each gene across all other genes in static (UT and MMS) and differential (DF) networks.
- Table S5 - Enrichment of functional crosstalk between various bioprocesses in static (UT and MMS) and differential (DF) networks .
- Table S6 - Single gene deletion mutants (from Nichols et al. 2011) showing sensitivity to drugs targeting cell division, metabolism, as well as DNA repair and recombination processes.
- Table S7 - Known or predicted mRNA targets showing alleviating GIs with cognate sRNAs in static networks.
- Table S8 - List of gene pairs with GI scores in differential (DF) network.
- Table S9 - List of DNA-damage response specific GIs in the differential (DF) network .
- Table S10 - Hub genes from the indicated processes showing the number of aggravating and alleviating GIs in the differential (DF) network.
- Table S11 - List of module-module interactions in the differential network.
- Table S12 - Top 5 percentile GI co-conservation between processes in static (UT, Sheet 3; MMS, Sheet 4) and differential (DF, Sheet 5) .
- Table S13 - Protein-BLAST searches to select E. coli Paralogs (Sheet 1), gene duplicates screened in this study (Sheet 2), and Pearson correlation coefficient (PCC) scores of gene duplicates .
- Table S14 - Bacterial strains and oligonucleotides (for preparation of DNA and RNA substrates) used in this study.
Zipped Files
- All Supporting Materials - Zipped Supporting Material
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