Emili Lab
Babu Lab E.coli  cell envelope protein complexes

Supporting Materials

Tables

• Supplementary Table 1   — Topological classification of the E. coli proteome and target cell envelope protein selection for AP/MS screens
• Supplementary Table 2   — Reference set of interactions compiled from EcoCyc
• Supplementary Table 3   — List of 12,801 high-confidence interacting protein pairs, along with their ΣLLS scores, in the cell envelope network
• Supplementary Table 4   — Interactions pertaining to physiological relevance and physical membrane transport metabolon
• Supplementary Table 5   — Mutations in genes encoding interacting CEPs sensitive to drugs from the large-scale phenomics screens (Nichols et al., 2011)
• Supplementary Table 6   — Validation of cePPIs by B2H and Y2H
• Supplementary Table 7   — Putative (or novel) CEP complexes and their subunits identified by the core-attachment based clustering algorithm
• Supplementary Table 8   — Enrichment analysis on drug hypersensitivity among the components of distinct CEP complexes
• Supplementary Table 9 — Evolutionary conservation of E. coli CEP complexes based on the orthologous relationships across diverse classes of bacteria
• Supplementary Table 10 — Summary of physical interaction overlap, BlastP sequence similarity, mRNA expression and protein abundances from the pairwise comparison of paralogous E.coli CEPs
• Supplementary Table 11 — List of E. coli strains, plasmids, oligonucleotides and detergents used in this study

CEP predicted complexes

• CEP complexes — Cytoscape network of E.coli CEP complexes predicted in this study

Zipped Files

• All Supplementary Tables — Zipped Supplementary Tables
• cePPI from APMS raw data — Zipped Unfiltered Raw Data

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